AQP4-AS1 Can Regulate the Expression of Ferroptosis-Related Regulator ALOX15 through Competitive Binding with miR-4476 in Lung Adenocarcinoma

Lin Du; Geng Xu; Xiuqiang Zhang; Zhiwei Zhang; Yang Yang; Hongsheng Teng; Tao Yang

doi:10.1055/s-0044-1789199

Global Medical Genetics (Dec 2024)

AQP4-AS1 Can Regulate the Expression of Ferroptosis-Related Regulator ALOX15 through Competitive Binding with miR-4476 in Lung Adenocarcinoma

Lin Du,
Geng Xu,
Xiuqiang Zhang,
Zhiwei Zhang,
Yang Yang,
Hongsheng Teng,
Tao Yang

Affiliations

Lin Du: Department of Thoracic Surgery, Tianjin Fifth Center Hospital, Tianjin, China
Geng Xu: Department of Thoracic Surgery, Tianjin Fifth Center Hospital, Tianjin, China
Xiuqiang Zhang: Department of Thoracic Surgery, Tianjin Fifth Center Hospital, Tianjin, China
Zhiwei Zhang: Department of Thoracic Surgery, Tianjin Fifth Center Hospital, Tianjin, China
Yang Yang: Department of Thoracic Surgery, Tianjin Fifth Center Hospital, Tianjin, China
Hongsheng Teng: Department of Thoracic Surgery, Tianjin Fifth Center Hospital, Tianjin, China
Tao Yang: Department of Thoracic Surgery, Tianjin Fifth Center Hospital, Tianjin, China

DOI: https://doi.org/10.1055/s-0044-1789199
Journal volume & issue: Vol. 11, no. 04
pp. 241 – 250

Abstract

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Background The AQP4-AS1/miR-4476-ALOX15 regulatory axis was discovered in previous studies. We aimed to investigate the regulatory mechanism of the ferroptosis-related regulator ALOX15 by AQP4-AS1 and miR-4476 in lung adenocarcinoma (LUAD) and find new targets for clinical treatment.

Published in Global Medical Genetics

ISSN: 2699-9404 (Online)
Publisher: Georg Thieme Verlag KG
Country of publisher: Germany
LCC subjects: Science: Biology (General): Genetics; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.thieme.com/books-main/genetics/product/5705-global-medical-genetics

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