PLoS ONE (Jan 2017)

A tissue microRNA signature that predicts the prognosis of breast cancer in young women.

  • Ai Hironaka-Mitsuhashi,
  • Juntaro Matsuzaki,
  • Ryou-U Takahashi,
  • Masayuki Yoshida,
  • Yutaka Nezu,
  • Yusuke Yamamoto,
  • Sho Shiino,
  • Takayuki Kinoshita,
  • Toshikazu Ushijima,
  • Nobuyoshi Hiraoka,
  • Chikako Shimizu,
  • Kenji Tamura,
  • Takahiro Ochiya

DOI
https://doi.org/10.1371/journal.pone.0187638
Journal volume & issue
Vol. 12, no. 11
p. e0187638

Abstract

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Since breast cancers in young women are generally aggressive, young patients tend to be intensively treated with anti-cancer drugs. To optimize the strategy for treatment, particularly in young women, prognostic biomarkers are urgently required. The objective of this study was to identify a tissue microRNA (miRNA) signature that predicts prognosis in young breast cancer patients. Total RNA from 45 breast cancer patients aged 0.7. Five of the miRNAs were validated by qRT-PCR, and the expression levels of three of those five (miR-183-5p, miR-194-5p, and miR-1285-5p), both alone and in combination, were associated with OS. In conclusion, we identified three candidate miRNAs that could be used separately or in combination as prognostic biomarkers in young breast cancer patients. This miRNA signature may enable selection of better treatment choices for young women with this disease.