ROLE OF OXIDATIVE STRESS IN PREECLAMPSIA AND NORMOTENSIVE PREGNANCIES

Abstract

Preeclampsia is described as a systemic illness associated with pregnancy. It is characterized by symptoms such as edema, proteinuria (the presence of excess proteins in the urine), hypertension (high blood pressure), and dysfunction. Recent research has extensively investigated the role of oxidative stress in the pathophysiology of preeclampsia. Oxidative stress refers to an imbalance between the production of reactive oxygen species and the body's ability to detoxify them or repair the resulting damage. Despite the research focus on oxidative stress, there is currently no consensus among researchers regarding the mechanisms that lead to the occurrence of preeclampsia in expectant mothers. The present review aims to advance the understanding of the underlying causes of preeclampsia by addressing the main biomarkers of oxidative stress. In summary, preeclampsia is a complex condition associated with pregnancy, and its pathophysiology has been the subject of extensive research, particularly in connection to oxidative stress. However, the lack of agreement among researchers indicates that the exact mechanisms leading to preeclampsia in expectant mothers are still not fully understood and may vary across different studies or perspectives.

Keywords

• preeclampsia
• oxidative stress
• antioxidant system
• peroxidation