The cryo-EM structure of the bacterial flagellum cap complex suggests a molecular mechanism for filament elongation

Natalie S. Al-Otaibi; Aidan J. Taylor; Daniel P. Farrell; Svetomir B. Tzokov; Frank DiMaio; David J. Kelly; Julien R. C. Bergeron

doi:10.1038/s41467-020-16981-4

Nature Communications (Jun 2020)

The cryo-EM structure of the bacterial flagellum cap complex suggests a molecular mechanism for filament elongation

Natalie S. Al-Otaibi,
Aidan J. Taylor,
Daniel P. Farrell,
Svetomir B. Tzokov,
Frank DiMaio,
David J. Kelly,
Julien R. C. Bergeron

Affiliations

Natalie S. Al-Otaibi: Department of Molecular Biology and Biotechnology, the University of Sheffield
Aidan J. Taylor: Department of Molecular Biology and Biotechnology, the University of Sheffield
Daniel P. Farrell: Department of Biochemistry, University of Washington
Svetomir B. Tzokov: Department of Molecular Biology and Biotechnology, the University of Sheffield
Frank DiMaio: Department of Biochemistry, University of Washington
David J. Kelly: Department of Molecular Biology and Biotechnology, the University of Sheffield
Julien R. C. Bergeron: Department of Molecular Biology and Biotechnology, the University of Sheffield

DOI: https://doi.org/10.1038/s41467-020-16981-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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FliD forms a cap complex at the tip of bacterial flagella and is essential for flagellum filament assembly. Here, the authors present the cryo-EM structure of the Campylobacter jejuni cap complex, revealing a pentameric assembly of FliD and further show that the C. jejuni flagellum filament is 11-stranded.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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