Nature Communications (Nov 2018)

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

  • Chae Ho Lim,
  • Qi Sun,
  • Karan Ratti,
  • Soung-Hoon Lee,
  • Ying Zheng,
  • Makoto Takeo,
  • Wendy Lee,
  • Piul Rabbani,
  • Maksim V. Plikus,
  • Jason E. Cain,
  • David H. Wang,
  • D. Neil Watkins,
  • Sarah Millar,
  • M. Mark Taketo,
  • Peggy Myung,
  • George Cotsarelis,
  • Mayumi Ito

DOI
https://doi.org/10.1038/s41467-018-07142-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

On wounding, scar formation in mammals arises causing no hair follicle regeneration, but it is unclear if scarring precludes regeneration. Here, the authors show that if Sonic hedgehog signaling is activated in the wound, an inductive dermal niche forms, enabling regeneration and hair follicle formation.