Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis

Abstract

: Leptospirosis becomes severe, with a fatality rate of >10%, and manifests as severe lung injury accompanied by acute kidney injury. Using urine and blood samples of 112 patients with leptospirosis, osteopontin (OPN), galectin-9 (Gal-9) and other kidney-related biomarkers were measured to understand the pathological and diagnostic roles of OPN and Gal-9 in leptospirosis. Plasma levels of full-length (FL)-OPN (pFL-OPN) (p p p n = 30), as were levels of several indicators of renal toxicity: serum cystatin C (p N-acetyl-β-glucosaminidase (NAG)/creatinine (p p r = −0.24, p r = 0.41, p r = 0.35, p r = 0.33, p r = 0.33, p p p < 0.001) were observed. Our results demonstrate that pFL-OPN reflect kidney injury among patients with leptospirosis.

Keywords

• leptospirosis
• biomarker
• osteopontin
• galectin-9
• cystatin C
• clusterin