Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors

Sabra I. Djomehri; Maria E. Gonzalez; Felipe da Veiga Leprevost; Shilpa R. Tekula; Hui-Yin Chang; Marissa J. White; Ashley Cimino-Mathews; Boris Burman; Venkatesha Basrur; Pedram Argani; Alexey I. Nesvizhskii; Celina G. Kleer

doi:10.1038/s41467-020-15283-z

Nature Communications (Apr 2020)

Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors

Sabra I. Djomehri,
Maria E. Gonzalez,
Felipe da Veiga Leprevost,
Shilpa R. Tekula,
Hui-Yin Chang,
Marissa J. White,
Ashley Cimino-Mathews,
Boris Burman,
Venkatesha Basrur,
Pedram Argani,
Alexey I. Nesvizhskii,
Celina G. Kleer

Affiliations

Sabra I. Djomehri: Department of Pathology, University of Michigan Medical School
Maria E. Gonzalez: Department of Pathology, University of Michigan Medical School
Felipe da Veiga Leprevost: Department of Pathology, University of Michigan Medical School
Shilpa R. Tekula: Department of Pathology, University of Michigan Medical School
Hui-Yin Chang: Department of Pathology, University of Michigan Medical School
Marissa J. White: Department of Pathology, Johns Hopkins University
Ashley Cimino-Mathews: Department of Pathology, Johns Hopkins University
Boris Burman: Department of Pathology, University of Michigan Medical School
Venkatesha Basrur: Department of Pathology, University of Michigan Medical School
Pedram Argani: Department of Pathology, Johns Hopkins University
Alexey I. Nesvizhskii: Department of Pathology, University of Michigan Medical School
Celina G. Kleer: Department of Pathology, University of Michigan Medical School

DOI: https://doi.org/10.1038/s41467-020-15283-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Metaplastic breast carcinoma (MBC) is among the most aggressive subtypes of triple-negative breast cancer (TNBC) but the underlying proteome profiles are unknown. Here, the authors characterize the protein signatures of human MBC tissue samples and their relationship to TNBC and normal breast tissue.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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