Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs

Samantha L. Sanford; Griffin A. Welfer; Bret D. Freudenthal; Patricia L. Opresko

doi:10.1038/s41467-020-19115-y

Nature Communications (Oct 2020)

Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs

Samantha L. Sanford,
Griffin A. Welfer,
Bret D. Freudenthal,
Patricia L. Opresko

Affiliations

Samantha L. Sanford: Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health and UPMC Hillman Cancer Center
Griffin A. Welfer: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center
Bret D. Freudenthal: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center
Patricia L. Opresko: Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health and UPMC Hillman Cancer Center

DOI: https://doi.org/10.1038/s41467-020-19115-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Telomerase enzymes add telomeric repeats to the end of linear chromosomes. Here the authors reveal mechanisms by which oxidized dNTPs and therapeutic dNTPs inhibit telomerase-mediated telomere elongation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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