Microwave assisted synthesis of novel thiazolidinone analogues as possible bioactive agents

Abstract

A series of 5-{[(6-substituted-2-hydroxyquinolin-3-yl)methylidene]/5-[(7-substitutedtetrazolo[1,5-a]quinoline-4-yl)methylidene]}-2-[(4-substitutedphenyl)amino]-1,3-thiazol-4(5H)-one was successfully synthesized under solvent free conditions by microwave irradiation in high yield. Structures of these newly synthesized compounds were established on the basis of spectral and analytical data. These novel compounds were also evaluated for their in vitro antioxidant, antibacterial and antifungal activity.

Keywords

• 4-Thiazolidinone
• Solvent free reaction
• Microwave assisted synthesis
• Antioxidant
• Antibacterial
• Antifungal activity