Risk factors analysis for BRAF gene V600E mutation in patients with infiltrative follicular papillary thyroid carcinoma

Abstract

Objective To investigate the risk factors for BRAF gene V600E mutation in patients with infiltrative follicular papillary thyroid carcinoma (IF-PTC). Methods A total of 134 patients with IF-PTC who underwent surgical treatment in our hospital from August 2019 to July 2023 were enrolled, and according to the presence or absence of BRAF gene V600E mutation, they were divided into mutation group and non-mutation group. The two groups were compared in terms of age, sex, and comorbidity with Hashimoto’s thyroiditis, and related indicators were collected, including the number, size, margin, calcification, echo, capsule invasion, and cervical lymph node metastasis of tumor lesions. The multivariate logistic regression model was used to investigate the risk factors for BRAF gene V600E mutation in the patients with IF-PTC. Results In this study, the patients with BRAF gene V600E mutation accounted for 67.16%. The univariate analysis showed that there were significant differences between the two groups in age, the number of lesions, and the constituent ratio of patients with capsule invasion (χ2=7.937-8.874,P<0.05). The multivariate logistic regression analysis showed that age ≥55 years, multifocal tumor, and capsular invasion were independent risk factors for BRAF gene V600E mutation in IF-PTC patients (P<0.05). Conclusion Age ≥55 years, multifocal tumor, and capsular invasion are independent risk factors for BRAF gene V600E mutations in IF-PTC patients.

Keywords

• thyroid cancer, papillary|proto-oncogene proteins b-raf|mutation|risk factors