Nature Communications (Jun 2017)
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis
- Ismail Sergin,
- Trent D. Evans,
- Xiangyu Zhang,
- Somashubhra Bhattacharya,
- Carl J. Stokes,
- Eric Song,
- Sahl Ali,
- Babak Dehestani,
- Karyn B. Holloway,
- Paul S. Micevych,
- Ali Javaheri,
- Jan R. Crowley,
- Andrea Ballabio,
- Joel D. Schilling,
- Slava Epelman,
- Conrad C. Weihl,
- Abhinav Diwan,
- Daping Fan,
- Mohamed A. Zayed,
- Babak Razani
Affiliations
- Ismail Sergin
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Trent D. Evans
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Xiangyu Zhang
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Somashubhra Bhattacharya
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Carl J. Stokes
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Eric Song
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Sahl Ali
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Babak Dehestani
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Karyn B. Holloway
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Paul S. Micevych
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Ali Javaheri
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Jan R. Crowley
- Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine
- Andrea Ballabio
- Telethon Institute of Genetics and Medicine
- Joel D. Schilling
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Slava Epelman
- Peter Munk Cardiac Center, University Health Network
- Conrad C. Weihl
- Department of Neurology, Washington University School of Medicine
- Abhinav Diwan
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Daping Fan
- Department of Cell Biology and Anatomy, University of South Carolina School of Medicine
- Mohamed A. Zayed
- Department of Surgery, Washington University School of Medicine
- Babak Razani
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms15750
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 20
Abstract
Dysfunction of autophagy in plaque macrophages aggravates atherosclerosis. Here the authors show that induction of macrophage autophagy–lysosomal biogenesis either genetically by overexpression of the master transcriptional regulator of this process, TFEB, or pharmacologically with trehalose is atheroprotective.
