Activation of neural lineage networks and ARHGEF2 in enzalutamide-resistant and neuroendocrine prostate cancer and association with patient outcomes

Shu Ning; Jinge Zhao; Alan P. Lombard; Leandro S. D’Abronzo; Amy R. Leslie; Masuda Sharifi; Wei Lou; Chengfei Liu; Joy C. Yang; Christopher P. Evans; Eva Corey; Hong-Wu Chen; Aiming Yu; Paramita M. Ghosh; Allen C. Gao

doi:10.1038/s43856-022-00182-9

Communications Medicine (Sep 2022)

Activation of neural lineage networks and ARHGEF2 in enzalutamide-resistant and neuroendocrine prostate cancer and association with patient outcomes

Shu Ning,
Jinge Zhao,
Alan P. Lombard,
Leandro S. D’Abronzo,
Amy R. Leslie,
Masuda Sharifi,
Wei Lou,
Chengfei Liu,
Joy C. Yang,
Christopher P. Evans,
Eva Corey,
Hong-Wu Chen,
Aiming Yu,
Paramita M. Ghosh,
Allen C. Gao

Affiliations

Shu Ning: Department of Urologic Surgery, University of California Davis
Jinge Zhao: Department of Urologic Surgery, University of California Davis
Alan P. Lombard: Department of Urologic Surgery, University of California Davis
Leandro S. D’Abronzo: Department of Urologic Surgery, University of California Davis
Amy R. Leslie: Department of Urologic Surgery, University of California Davis
Masuda Sharifi: Department of Urologic Surgery, University of California Davis
Wei Lou: Department of Urologic Surgery, University of California Davis
Chengfei Liu: Department of Urologic Surgery, University of California Davis
Joy C. Yang: Department of Urologic Surgery, University of California Davis
Christopher P. Evans: Department of Urologic Surgery, University of California Davis
Eva Corey: Department of Urology, University of Washington
Hong-Wu Chen: UC Davis Comprehensive Cancer Center, University of California Davis
Aiming Yu: UC Davis Comprehensive Cancer Center, University of California Davis
Paramita M. Ghosh: Department of Urologic Surgery, University of California Davis
Allen C. Gao: Department of Urologic Surgery, University of California Davis

DOI: https://doi.org/10.1038/s43856-022-00182-9
Journal volume & issue: Vol. 2, no. 1
pp. 1 – 12

Abstract

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Ning et al. report expression of a neural lineage gene signature in enzalutamide-resistant prostate cancer cells and datasets from patients with neuroendocrine prostate cancer. One of these genes, ARHGEF2, is associated with poor overall and disease-free survival in patients with castration-resistant disease and supports cell viability in vitro.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

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