Imbalance in resting state functional connectivity is associated with eating behaviors and adiposity in children

Abstract

Background and Hypothesis: Over the past 30 years, childhood obesity in the US has nearly doubled, while obesity has tripled among adolescents. Non-homeostatic eating, influenced by impulsivity and inhibition, may undermine successful long-term weight loss. We hypothesized that unhealthy eating habits and adiposity among children are associated with functional connectivity between brain regions associated with impulsivity, response inhibition, and reward. Methods: We analyzed resting state functional magnetic resonance images from 38 children, ages 8–13. Using seed-based resting state functional connectivity, we quantified connectivity between brain regions associated with response inhibition (inferior parietal lobe [IPL]), impulsivity (frontal pole), and reward (nucleus accumbens [NAc]). We assessed the relationship of resting state functional connectivity with adiposity, quantified by BMI z-score, and eating behaviors, as measured by the Child Eating Behaviour Questionnaire (CEBQ). We computed an imbalance measure—the difference between [frontal pole:NAC] and [ipl:nac] functional connectivity—and investigated the relationship of this imbalance with eating behaviors and adiposity. Results: As functional connectivity imbalance is increasingly biased toward impulsivity, adiposity increases. Similarly, as impulsivity-biased imbalance increases, food approach behaviors increase and food avoidance behaviors decrease. Increased adiposity is associated with increased food approach behaviors and decreased food avoidance behaviors. Conclusions: In the absence of any explicit eating-related stimuli, the developing brain is primed toward food approach and away from food avoidance behavior with increasing adiposity. Imbalance in resting state functional connectivity that is associated with non-homeostatic eating develops during childhood, as early as 8–13 years of age. Our results indicate the importance of identifying children at risk for obesity for earlier intervention. In addition to changing eating habits and physical activity, strategies that normalize neural functional connectivity imbalance are needed to maintain healthy weight. Mindfulness may be one such approach as it is associated with increased response inhibition and decreased impulsivity.

Keywords

• Methods in neuroscience
• Magnetic resonance imaging
• Neural circuits
• Obesity
• Methods to study human brain function
• Neuroscience