Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR

Caleb Singleton; Robert Brkljača; Sylvia Urban

doi:10.3390/md16060205

Marine Drugs (Jun 2018)

Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR

Caleb Singleton,
Robert Brkljača,
Sylvia Urban

Affiliations

Caleb Singleton: School of Science (Applied Chemistry and Environmental Science), RMIT University, GPO Box 2476, Melbourne, VIC 3001, Australia
Robert Brkljača: School of Science (Applied Chemistry and Environmental Science), RMIT University, GPO Box 2476, Melbourne, VIC 3001, Australia
Sylvia Urban: School of Science (Applied Chemistry and Environmental Science), RMIT University, GPO Box 2476, Melbourne, VIC 3001, Australia

DOI: https://doi.org/10.3390/md16060205
Journal volume & issue: Vol. 16, no. 6
p. 205

Abstract

Read online

The absolute configuration of retroflexanone (1) and a closely related phlorogluinol (2) was established using the advanced Mosher method and by application of HPLC-NMR. HPLC-NMR permitted a small scale Mosher method analysis to be carried out on these unstable phloroglucinols.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

About the journal

Abstract

Keywords