Immunohistochemical characteristics of renal cell carcinoma with intravenous extension

Abstract

Up to this day, there is still no sufficient data on immunohistochemical characteristics of intravenous neoplastic thrombi, as well as there is still no general theory about their formation process. Aim. In order to clarify the pathogenesis of macroscopic intravenous proliferation of renal cell carcinoma, both with and without intravenous invasion, in the group of 94 patients the expression of MMP-9, type IV collagen, a marker of endothelial cells (CD 31) and vascular endothelial growth factor (VEGF) were assessed by immunohistochemical tests. Methods and results. It was determined, that the expression of MMP-9 and VEGF was significantly higher in the group with macroscopic intravenous tumor proliferation, and it did not correlate either with the extent of thrombus or primary tumor size. Conclusion. The results are evident of important role of the matrix metalloproteinase-9 and VEGF in the intravenous proliferation of RCC pathogenesis.

Keywords

• Renal Cell Carcinoma
• Thrombosis
• Matrix Metalloproteinase 9
• Immunohistochemistry