Cell Reprogramming for Regeneration and Repair of the Nervous System

Isaac H. Clark; Alex Roman; Emily Fellows; Swathi Radha; Susanna R. Var; Zachary Roushdy; Samuel M. Borer; Samantha Johnson; Olivia Chen; Jacob S. Borgida; Aleta Steevens; Anala Shetty; Phoebe Strell; Walter C. Low; Andrew W. Grande

doi:10.3390/biomedicines10102598

Biomedicines (Oct 2022)

Cell Reprogramming for Regeneration and Repair of the Nervous System

Isaac H. Clark,
Alex Roman,
Emily Fellows,
Swathi Radha,
Susanna R. Var,
Zachary Roushdy,
Samuel M. Borer,
Samantha Johnson,
Olivia Chen,
Jacob S. Borgida,
Aleta Steevens,
Anala Shetty,
Phoebe Strell,
Walter C. Low,
Andrew W. Grande

Affiliations

Isaac H. Clark: Department of Biomedical Engineering, Biomedical Engineering Graduate Program, University of Minnesota, Minneapolis, MN 55455, USA
Alex Roman: Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
Emily Fellows: Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
Swathi Radha: Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
Susanna R. Var: Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
Zachary Roushdy: Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
Samuel M. Borer: Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
Samantha Johnson: Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
Olivia Chen: Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
Jacob S. Borgida: Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
Aleta Steevens: Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
Anala Shetty: Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
Phoebe Strell: Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
Walter C. Low: Department of Biomedical Engineering, Biomedical Engineering Graduate Program, University of Minnesota, Minneapolis, MN 55455, USA
Andrew W. Grande: Department of Biomedical Engineering, Biomedical Engineering Graduate Program, University of Minnesota, Minneapolis, MN 55455, USA

DOI: https://doi.org/10.3390/biomedicines10102598
Journal volume & issue: Vol. 10, no. 10
p. 2598

Abstract

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A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cell types through cellular reprogramming of native cells as a promising therapy to replenish lost or diminished cell populations in various neurological diseases. This review provides an in-depth analysis of the current viral vectors, genes of interest, and target cellular populations that have been studied, as well as the challenges and future directions of these novel therapies. Furthermore, the mechanisms by which cellular reprogramming could be optimized as treatment in neurological diseases and a review of the most recent cellular reprogramming in vitro and in vivo studies will also be discussed.

Published in Biomedicines

ISSN: 2227-9059 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/biomedicines

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Abstract

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