PLoS ONE (Jul 2010)

Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.

  • Amelia Guadalupe-Grau,
  • Francisco Germán Rodríguez-González,
  • Jesús Gustavo Ponce-González,
  • Cecilia Dorado,
  • Hugo Olmedillas,
  • Teresa Fuentes,
  • Jorge Pérez-Gómez,
  • Joaquín Sanchís-Moysi,
  • Bonifacio Nicolás Díaz-Chico,
  • José A L Calbet

DOI
https://doi.org/10.1371/journal.pone.0011529
Journal volume & issue
Vol. 5, no. 7
p. e11529

Abstract

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BackgroundTo determine whether androgen receptor (AR) CAG (polyglutamine) and GGN (polyglycine) polymorphisms influence bone mineral density (BMD), osteocalcin and free serum testosterone concentration in young men.Methodology/principal findingsWhole body, lumbar spine and femoral bone mineral content (BMC) and BMD, Dual X-ray Absorptiometry (DXA), AR repeat polymorphisms (PCR), osteocalcin and free testosterone (ELISA) were determined in 282 healthy men (28.6+/-7.6 years). Individuals were grouped as CAG short (CAG(S)) if harboring repeat lengths of 21, and GGN was considered short (GGN(S)) or long (GGN(L)) if GGN 23. There was an inverse association between logarithm of CAG and GGN length and Ward's Triangle BMC (r = -0.15 and -0.15, PConclusionAR polymorphisms have an influence on BMC and BMD in healthy adult humans, which cannot be explained through effects in osteoblastic activity.