Effectiveness of Algan Hemostatic Agent in Bleeding Control: An Experimental Kidney Incision Model

Abstract

Aim:The purpose of this study is to evaluate the hemostatic efficacy of a novel plant originated blood stopper which is called Algan Hemostatic Agent (AHA) in uncontrolled kidney incision bleeding model.Methods:The study was conducted with thirty-two rats 5-7 weeks old. The rats were randomly divided into 4 groups, each consisting of eight rats (Group 1: heparinized saline, 2: heparinized AHA, 3: non-heparinized saline, 4: non-heparinized AHA). Experimental kidney incision was made, and saline soaked sponge was applied to the control group and AHA to the study group.Results:The duration of bleeding was significantly shorter in the AHA group compared to the control group. The AHA has controlled the bleeding in the heparinized and non-heparinized groups 5±1.19 and 3±0.91 seconds respectively (p<0.001). In the control group, hemorrhage was controlled in the heparinized and non-heparinized group 180.6±25.4 and 125.4±21 seconds respectively.Conclusion:This study demonstrated that the AHA is useful in controlling bleeding in the Rat kidney incision model.

Keywords

• algan hemostatic agent
• hemostasis
• rats
• kidney
• bleeding