Clinical Ophthalmology (Oct 2022)
Retinopathy of Prematurity: A Study of Incidence and Risk Factors in a Tertiary Hospital in Vietnam
Abstract
Thi Thanh Binh Nguyen,1,* Van Trieu Bui,1,* Vo Phuong Thao Pham,1 Thi Ny Pham2 1Department of Pediatrics, University of Medicine and Pharmacy, Hue University, Hue City, Vietnam; 2Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy Hospital, Hue University, Hue City, Vietnam*These authors contributed equally to this workCorrespondence: Thi Thanh Binh Nguyen, Department of Pediatrics, University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue City, 49000, Vietnam, Email [email protected]; [email protected]: To determine the incidence and risk factors for the development of retinopathy of prematurity (ROP) in the neonatal intensive care unit (NICU) of Hue Central Hospital, Vietnam.Methods: A prospective study was performed in 214 preterm infants with gestational age (GA) ≤ 33 weeks and/or ≤ 1800 grams of birth weight (BW) or infants with a GA > 33 weeks and a BW > 1800 grams with an unstable clinical course who were screened for ROP in Hue Central Hospital, Vietnam.Results: Fifty-eight infants (27.1%) developed ROP; 39.7% cases were stage 1, 34.5% cases were stage 2, and 25.8% cases were stage 3. Gestational age (GA), birth weight, anemia, sepsis, respiratory distress syndrome, total days on oxygen supplementation > 1 week, continuous positive airway pressure (CPAP), mechanical ventilation, blood transfusion, and surfactant had a significant association with ROP in univariate analysis (p< 0.05). Using multivariate analysis, GA less than 32 weeks, sepsis, and CPAP/mechanical ventilation remained independent risk factors for ROP development.Conclusion: The incidence of ROP in Vietnam was 27.1%. A GA less than 32 weeks, sepsis, and CPAP/mechanical ventilation are important risk factors for developing ROP.Keywords: retinopathy of prematurity, preterm infants, low birth weight infants
