Nature Communications (Jul 2022)
Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age
- Birgit Burkhardt,
- Ulf Michgehl,
- Jonas Rohde,
- Tabea Erdmann,
- Philipp Berning,
- Katrin Reutter,
- Marius Rohde,
- Arndt Borkhardt,
- Thomas Burmeister,
- Sandeep Dave,
- Alexandar Tzankov,
- Martin Dugas,
- Sarah Sandmann,
- Falko Fend,
- Jasmin Finger,
- Stephanie Mueller,
- Nicola Gökbuget,
- Torsten Haferlach,
- Wolfgang Kern,
- Wolfgang Hartmann,
- Wolfram Klapper,
- Ilske Oschlies,
- Julia Richter,
- Udo Kontny,
- Mathias Lutz,
- Britta Maecker-Kolhoff,
- German Ott,
- Andreas Rosenwald,
- Reiner Siebert,
- Arend von Stackelberg,
- Brigitte Strahm,
- Wilhelm Woessmann,
- Martin Zimmermann,
- Myroslav Zapukhlyak,
- Michael Grau,
- Georg Lenz
Affiliations
- Birgit Burkhardt
- Pediatric Hematology, Oncology and BMT, University Hospital Münster
- Ulf Michgehl
- Pediatric Hematology, Oncology and BMT, University Hospital Münster
- Jonas Rohde
- Pediatric Hematology, Oncology and BMT, University Hospital Münster
- Tabea Erdmann
- Department of Medicine A, Hematology, Oncology, and Pneumology, University Hospital Münster
- Philipp Berning
- Department of Medicine A, Hematology, Oncology, and Pneumology, University Hospital Münster
- Katrin Reutter
- Pediatric Hematology, Oncology and BMT, University Hospital Münster
- Marius Rohde
- Pediatric Hematology and Oncology, University Hospital Giessen
- Arndt Borkhardt
- Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital Medical Faculty, Heinrich-Heine-University
- Thomas Burmeister
- Department of Hematology, Oncology and Tumor Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Sandeep Dave
- Center for Genomic and Computational Biology and Department of Medicine, Duke University
- Alexandar Tzankov
- Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel
- Martin Dugas
- Institute of Medical Informatics, Heidelberg University Hospital
- Sarah Sandmann
- Institute of Medical Informatics, University of Münster
- Falko Fend
- Institute of Pathology and Neuropathology and Comprehensive Cancer Centre Tübingen, University Hospital Tübingen, Eberhard-Karls-University
- Jasmin Finger
- Pediatric Hematology, Oncology and BMT, University Hospital Münster
- Stephanie Mueller
- Pediatric Hematology, Oncology and BMT, University Hospital Münster
- Nicola Gökbuget
- Department of Medicine II, Goethe University
- Torsten Haferlach
- MLL Munich Leukemia Laboratory
- Wolfgang Kern
- MLL Munich Leukemia Laboratory
- Wolfgang Hartmann
- Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital of Münster
- Wolfram Klapper
- Department of Pathology, Hematopathology Section, University Hospital Schleswig-Holstein
- Ilske Oschlies
- Department of Pathology, Hematopathology Section, University Hospital Schleswig-Holstein
- Julia Richter
- Department of Pathology, Hematopathology Section, University Hospital Schleswig-Holstein
- Udo Kontny
- Section of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Department of Pediatric and Adolescent Medicine, RWTH Aachen University Hospital
- Mathias Lutz
- Hematology and Oncology, Medical Faculty, University of Augsburg
- Britta Maecker-Kolhoff
- Hannover Medical School, Department of Pediatric Hematology and Oncology
- German Ott
- Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology
- Andreas Rosenwald
- Institute of Pathology, Universität Würzburg and Comprehensive Cancer Centre Mainfranken (CCCMF)
- Reiner Siebert
- Institute of Human Genetics, Ulm University and Ulm University Medical Center
- Arend von Stackelberg
- Department of Pediatric Oncology Hematology, Charité - Universitätsmedizin Berlin
- Brigitte Strahm
- Department of Pediatrics and Adolescent Medicine Division of Pediatric Hematology and Oncology, Medical Center Faculty of Medicine, University of Freiburg
- Wilhelm Woessmann
- Pediatric Hematology and Oncology, University Medical Centre Hamburg-Eppendorf
- Martin Zimmermann
- Hannover Medical School, Department of Pediatric Hematology and Oncology
- Myroslav Zapukhlyak
- Department of Medicine A, Hematology, Oncology, and Pneumology, University Hospital Münster
- Michael Grau
- Department of Medicine A, Hematology, Oncology, and Pneumology, University Hospital Münster
- Georg Lenz
- Department of Medicine A, Hematology, Oncology, and Pneumology, University Hospital Münster
- DOI
- https://doi.org/10.1038/s41467-022-31355-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Survival outcomes in Burkitt lymphoma differ between adult and paediatric patients. Here, the authors show differences in mutational frequencies between age groups, and a transition between mutational profiles which occurs between 25 and 40 years.
