Metabolic balancing by miR-276 shapes the mosquito reproductive cycle and Plasmodium falciparum development

Abstract

Plasmodium growth is adapted to the reproductive cycle of mosquitoes, but underlying mechanisms are unclear. Here, Lampe et al. show that the blood-meal induced miR-276 balances the termination of the mosquito amino acid catabolism and egg development, providing nutrients for Plasmodium sporozoite development.