Nature Communications (Feb 2018)
Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
- Jun Wang,
- Georgia E. Hodes,
- Hongxing Zhang,
- Song Zhang,
- Wei Zhao,
- Sam A. Golden,
- Weina Bi,
- Caroline Menard,
- Veronika Kana,
- Marylene Leboeuf,
- Marc Xie,
- Dana Bregman,
- Madeline L. Pfau,
- Meghan E. Flanigan,
- Adelaida Esteban-Fernández,
- Shrishailam Yemul,
- Ali Sharma,
- Lap Ho,
- Richard Dixon,
- Miriam Merad,
- Ming-Hu Han,
- Scott J. Russo,
- Giulio M. Pasinetti
Affiliations
- Jun Wang
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Georgia E. Hodes
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Hongxing Zhang
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Song Zhang
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Wei Zhao
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Sam A. Golden
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Weina Bi
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Caroline Menard
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Veronika Kana
- Department of Oncological Sciences, Tisch Cancer Institute and Immunology Institute, Icahn School of Medicine at Mount Sinai
- Marylene Leboeuf
- Department of Oncological Sciences, Tisch Cancer Institute and Immunology Institute, Icahn School of Medicine at Mount Sinai
- Marc Xie
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Dana Bregman
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Madeline L. Pfau
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Meghan E. Flanigan
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Adelaida Esteban-Fernández
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Shrishailam Yemul
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Ali Sharma
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Lap Ho
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- Richard Dixon
- Department of Biological Science, University of North Texas
- Miriam Merad
- Department of Oncological Sciences, Tisch Cancer Institute and Immunology Institute, Icahn School of Medicine at Mount Sinai
- Ming-Hu Han
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Scott J. Russo
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Giulio M. Pasinetti
- Department of Neurology, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-017-02794-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Polyphenols have partial antidepressant effect without known mechanism. Here, the authors identify two phytochemicals from bioactive dietary polyphenols, show their antidepressant effect in a rodent model of depression, and that this effect is mediated by epigenetic and anti-inflammatory mechanisms.
