Nature Communications (Jun 2020)

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia

  • Katharina Leonards,
  • Marwa Almosailleakh,
  • Samantha Tauchmann,
  • Frederik Otzen Bagger,
  • Cécile Thirant,
  • Sabine Juge,
  • Thomas Bock,
  • Hélène Méreau,
  • Matheus F. Bezerra,
  • Alexandar Tzankov,
  • Robert Ivanek,
  • Régine Losson,
  • Antoine H. F. M. Peters,
  • Thomas Mercher,
  • Juerg Schwaller

DOI
https://doi.org/10.1038/s41467-020-16179-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

Read online

Loss of function mutations of NSD1 occur in blood cancers. Here, the authors report that NSD1 loss blocks erythroid differentiation which leads to an erythroleukemia-like disease in mice by impairing GATA1-induced target gene activation.