Nature Communications (Nov 2022)
Structural basis for activation of DNMT1
- Amika Kikuchi,
- Hiroki Onoda,
- Kosuke Yamaguchi,
- Satomi Kori,
- Shun Matsuzawa,
- Yoshie Chiba,
- Shota Tanimoto,
- Sae Yoshimi,
- Hiroki Sato,
- Atsushi Yamagata,
- Mikako Shirouzu,
- Naruhiko Adachi,
- Jafar Sharif,
- Haruhiko Koseki,
- Atsuya Nishiyama,
- Makoto Nakanishi,
- Pierre-Antoine Defossez,
- Kyohei Arita
Affiliations
- Amika Kikuchi
- Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi-ku
- Hiroki Onoda
- Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi-ku
- Kosuke Yamaguchi
- Université Paris Cité, CNRS, Epigenetics and Cell Fate
- Satomi Kori
- Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi-ku
- Shun Matsuzawa
- Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi-ku
- Yoshie Chiba
- Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo
- Shota Tanimoto
- Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo
- Sae Yoshimi
- Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi-ku
- Hiroki Sato
- Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi-ku
- Atsushi Yamagata
- Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research
- Mikako Shirouzu
- Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research
- Naruhiko Adachi
- Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK)
- Jafar Sharif
- Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS)
- Haruhiko Koseki
- Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS)
- Atsuya Nishiyama
- Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo
- Makoto Nakanishi
- Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo
- Pierre-Antoine Defossez
- Université Paris Cité, CNRS, Epigenetics and Cell Fate
- Kyohei Arita
- Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi-ku
- DOI
- https://doi.org/10.1038/s41467-022-34779-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
DNMT1 is an essential for maintaining genomic DNA methylation. Here, we report the cryo-EM structure of DNMT1 bound to ubiquitinated H3 and hemimethylated DNA, revealing structural insight into the activation mechanism of DNMT1.
