Communications Biology (Nov 2022)

The force of the myosin motor sets cooperativity in thin filament activation of skeletal muscles

  • Marco Caremani,
  • Matteo Marcello,
  • Ilaria Morotti,
  • Irene Pertici,
  • Caterina Squarci,
  • Massimo Reconditi,
  • Pasquale Bianco,
  • Gabriella Piazzesi,
  • Vincenzo Lombardi,
  • Marco Linari

DOI
https://doi.org/10.1038/s42003-022-04184-0
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 12

Abstract

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Sarcomeres of Ca2 + -activated demembranated fibres of rabbit soleus muscles show that the stress exerted by each motor protein on the thin filament determines the cooperativity in thin filament activation.