mBio (Apr 2021)
Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in Children
- Michael J. Bale,
- Mary Grace Katusiime,
- Daria Wells,
- Xiaolin Wu,
- Jonathan Spindler,
- Elias K. Halvas,
- Joshua C. Cyktor,
- Ann Wiegand,
- Wei Shao,
- Mark F. Cotton,
- Stephen H. Hughes,
- John W. Mellors,
- John M. Coffin,
- Gert U. Van Zyl,
- Mary F. Kearney
Affiliations
- Michael J. Bale
- HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, Maryland, USA
- Mary Grace Katusiime
- HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, Maryland, USA
- Daria Wells
- Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
- Xiaolin Wu
- Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
- Jonathan Spindler
- HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, Maryland, USA
- Elias K. Halvas
- Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
- Joshua C. Cyktor
- Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
- Ann Wiegand
- HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, Maryland, USA
- Wei Shao
- Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
- Mark F. Cotton
- Department of Pediatrics and Child Health, Tygerberg Children’s Hospital and Family Center for Research with Ubuntu, Stellenbosch University, Cape Town, South Africa
- Stephen H. Hughes
- ORCiD
- HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, Maryland, USA
- John W. Mellors
- Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
- John M. Coffin
- Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, USA
- Gert U. Van Zyl
- Division of Medical Virology, Stellenbosch University and National Health Laboratory Service Tygerberg, Cape Town, South Africa
- Mary F. Kearney
- HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, Maryland, USA
- DOI
- https://doi.org/10.1128/mBio.00568-21
- Journal volume & issue
-
Vol. 12,
no. 2
Abstract
HIV-1 integrates its genome into the DNA of host cells. Consequently, HIV-1 genomes are copied with the host cell DNA during cellular division.
