﻿Cytotoxic activity of Galantamine hydrobromide against HeLa cell line

Danka Obreshkova; Petar Atanasov; Mariya Chaneva; Stefka Ivanova; Stefan Balkanski; Lily Peikova

doi:10.3897/pharmacia.70.e109841

Pharmacia (Aug 2023)

Cytotoxic activity of Galantamine hydrobromide against HeLa cell line

Danka Obreshkova,
Petar Atanasov,
Mariya Chaneva,
Stefka Ivanova,
Stefan Balkanski,
Lily Peikova

Affiliations

Danka Obreshkova: Hospital Pharmacy, UMHATEM “N. I. Pirogov”,
Petar Atanasov: Clinic of Internal Diseases UMHATEM “N. I. Pirogov”
Mariya Chaneva: Clinic of Internal Diseases UMHATEM “N. I. Pirogov”
Stefka Ivanova: Bulgarian Pharmaceutical Science Society
Stefan Balkanski: Bulgarian Pharmaceutical Union
Lily Peikova: Medical University of Sofia

DOI: https://doi.org/10.3897/pharmacia.70.e109841
Journal volume & issue: Vol. 70, no. 3
pp. 619 – 623

Abstract

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Cytotoxic activity of Galantamine HBr against human cervical adenocarcinoma cell line HeLa in different concentrations (1.875 μМ ÷ 30 μМ) was evaluated. Inhibition of HeLa cell growth after treatment with Galantamine HBr and index of cell viability were determined. From the experimental results was proven that the drug exerts cytotoxic activity towards HeLa cell line, with antiproliferative activity presented as the value of IC50 = 30 μM ± 0.22.

Published in Pharmacia

ISSN: 0428-0296 (Print); 2603-557X (Online)
Publisher: Pensoft Publishers
Country of publisher: Bulgaria
LCC subjects: Medicine: Pharmacy and materia medica
Website: https://pharmacia.pensoft.net/

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