A convenient synthesis of β,β’-dioxochlorins: New application for Bobbitt's salt

Yunzhen Qin; Chunyu Cui; Changxiao Yang; Xuliang Jiang

Results in Chemistry (Jan 2024)

A convenient synthesis of β,β’-dioxochlorins: New application for Bobbitt's salt

Yunzhen Qin,
Chunyu Cui,
Changxiao Yang,
Xuliang Jiang

Affiliations

Yunzhen Qin: Department of Medicinal Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China
Chunyu Cui: Department of Medicinal Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China
Changxiao Yang: Department of Medicinal Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China
Xuliang Jiang: Corresponding author.; Department of Medicinal Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China

Journal volume & issue: Vol. 7
p. 101280

Abstract

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Oxidation of β-aminoporphyrins with 4-acetamido-2,2,6,6-tetramethylpiperidine−1-oxoammonium tetrafluoroborate (Bobbitt's salt) provides an efficient synthesis of the corresponding 2,3-dioxochlorins. The synthesis is simple and exhibit good universality. In addition, Bobbitt's salt can be further applied to oxidize more aromatic amines. Preliminary studies have shown that aromatic amines with structures similar to 9-aminophenanthrene can be selectively oxidized to corresponding ortho-diketones.

Published in Results in Chemistry

ISSN: 2211-7156 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: https://www.journals.elsevier.com/results-in-chemistry/

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