Chemoenzymatic Enantioselective Formal Synthesis of (-)-Gephyrotoxin-223

Abstract

(-)-Gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized in the presence of Candida Antartica lipase.

Keywords

• gephyrotoxin
• indolizidine
• chemoenzymatic
• candida antartica lipse
• alkaloids
• desymmetrization