BRCA2 Heterozygosity Delays Cytokinesis in Primary Human Fibroblasts

Asta Björk Jonsdottir; Maaike P. G. Vreeswijk; Ron Wolterbeek; Peter Devilee; Hans J. Tanke; Jorunn E. Eyfjörd; Karoly Szuhai

doi:10.3233/CLO-2009-0465

Cellular Oncology (Jan 2009)

BRCA2 Heterozygosity Delays Cytokinesis in Primary Human Fibroblasts

Asta Björk Jonsdottir,
Maaike P. G. Vreeswijk,
Ron Wolterbeek,
Peter Devilee,
Hans J. Tanke,
Jorunn E. Eyfjörd,
Karoly Szuhai

Affiliations

Asta Björk Jonsdottir: Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Maaike P. G. Vreeswijk: Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
Ron Wolterbeek: Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands
Peter Devilee: Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
Hans J. Tanke: Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
Jorunn E. Eyfjörd: Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Karoly Szuhai: Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

DOI: https://doi.org/10.3233/CLO-2009-0465
Journal volume & issue: Vol. 31, no. 3
pp. 191 – 201

Abstract

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Background: Inherited mutations in the tumour suppressor gene BRCA2 greatly increase the risk of developing breast, ovarian and other types of cancers. So far, most studies have focused on the role of BRCA-pathways in the maintenance of genomic stability.

Published in Cellular Oncology

ISSN: 1570-5870 (Print); 1875-8606 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

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