Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

Subhrajit Saha; Evelyn Aranda; Yoku Hayakawa; Payel Bhanja; Safinur Atay; N Patrik Brodin; Jiufeng Li; Samuel Asfaha; Laibin Liu; Yagnesh Tailor; Jinghang Zhang; Andrew K. Godwin; Wolfgang A. Tome; Timothy C. Wang; Chandan Guha; Jeffrey W. Pollard

doi:10.1038/ncomms13096

Nature Communications (Oct 2016)

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

Subhrajit Saha,
Evelyn Aranda,
Yoku Hayakawa,
Payel Bhanja,
Safinur Atay,
N Patrik Brodin,
Jiufeng Li,
Samuel Asfaha,
Laibin Liu,
Yagnesh Tailor,
Jinghang Zhang,
Andrew K. Godwin,
Wolfgang A. Tome,
Timothy C. Wang,
Chandan Guha,
Jeffrey W. Pollard

Affiliations

Subhrajit Saha: Department of Radiation Oncology, Albert Einstein College of Medicine & Montefiore Medical Center
Evelyn Aranda: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
Yoku Hayakawa: Department of Medicine, Division of Digestive and Liver Diseases, Irving Cancer Research Center, Columbia University
Payel Bhanja: Department of Radiation Oncology, Albert Einstein College of Medicine & Montefiore Medical Center
Safinur Atay: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center
N Patrik Brodin: Department of Radiation Oncology, Albert Einstein College of Medicine & Montefiore Medical Center
Jiufeng Li: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
Samuel Asfaha: Department of Medicine, Division of Digestive and Liver Diseases, Irving Cancer Research Center, Columbia University
Laibin Liu: Department of Radiation Oncology, Albert Einstein College of Medicine & Montefiore Medical Center
Yagnesh Tailor: Department of Medicine, Division of Digestive and Liver Diseases, Irving Cancer Research Center, Columbia University
Jinghang Zhang: Department of Microbiology and Immunology, Albert Einstein College of Medicine
Andrew K. Godwin: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center
Wolfgang A. Tome: Department of Radiation Oncology, Albert Einstein College of Medicine & Montefiore Medical Center
Timothy C. Wang: Department of Medicine, Division of Digestive and Liver Diseases, Irving Cancer Research Center, Columbia University
Chandan Guha: Department of Radiation Oncology, Albert Einstein College of Medicine & Montefiore Medical Center
Jeffrey W. Pollard: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine

DOI: https://doi.org/10.1038/ncomms13096
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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The intestinal stroma secretes WNT ligands but the role of WNT in intestinal repair is unclear. Here, the authors show that when WNT synthesis is ablated from stromal macrophages, the intestine morphology is normal but hypersensitive to radiation injury, implicating macrophage-derived WNT in intestinal repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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