Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO

Yunfu Lu; Feifei Chen; Qingmin Zhao; Qiao Cao; Rongrong Chen; Huiwen Pan; Yanhui Wang; Haixin Huang; Ruimin Huang; Qian Liu; Min Li; Taeok Bae; Haihua Liang; Lefu Lan

doi:10.1038/s41467-023-37310-5

Nature Communications (Mar 2023)

Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO

Yunfu Lu,
Feifei Chen,
Qingmin Zhao,
Qiao Cao,
Rongrong Chen,
Huiwen Pan,
Yanhui Wang,
Haixin Huang,
Ruimin Huang,
Qian Liu,
Min Li,
Taeok Bae,
Haihua Liang,
Lefu Lan

Affiliations

Yunfu Lu: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
Feifei Chen: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
Qingmin Zhao: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
Qiao Cao: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
Rongrong Chen: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
Huiwen Pan: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
Yanhui Wang: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
Haixin Huang: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Ruimin Huang: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Qian Liu: Department of Laboratory Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University
Min Li: Department of Laboratory Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University
Taeok Bae: Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest
Haihua Liang: College of Life Science, Northwest University
Lefu Lan: School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-023-37310-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 19

Abstract

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The two-component regulatory system VraRS regulates transcription of penicillin-binding protein 2 in response to cell wall antimicrobials. Here, Lu et al. show that an enzyme from the wall teichoic acid biosynthetic pathway of MRSA can also modulate the expression of virulence factors such as Staphylococcal protein A via VraRS.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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