Value of polymorphism of a gene of interleukin-17 (П-17а g-197a, il-17f his161arg) in a pathogenesis of the influenza IN children

Abstract

The results of research of occurrence of genotypes of a polymorphic marker of a gene of interleukin-17 (IL-17А G-197A, IL-17F His161Arg) in 141 children at a influenza are presented in the article. It is established, that genotypes G/A of gene IL-17А G-197A and His/Arg gene IL-17F His161Arg act as factors of protection in children at a seasonal influenza. And at a influenza A H1N1/v genotypes G/A of gene IL-17А G-197A and His/Arg gene IL-17F His161Arg are associated with risk of occurrence of a disease. Serious forms of a pandemic influenza are accompanied by frequent revealing of allele Arg and more rare - of His gene IL-17F His161Arg in comparison with not serious forms of a influenza A H1N1/v.

Keywords

• influenza
• children
• polymorphism
• interleukin