Frontiers in Bioengineering and Biotechnology (Sep 2023)

Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids

  • Herbert P. Jennissen

DOI
https://doi.org/10.3389/fbioe.2023.1226649
Journal volume & issue
Vol. 11

Abstract

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The constant release of human bone morphogenetic protein 2 (rhBMP-2) in the picomolar range (Pico-Stat) from PDLLA-biohybrids led to the detection of intrinsic novel pro- and anti-angiogenic functions of this cytokine. As integrant part in this perspective of previous work, first evidence for the binding of rhBMP-2, as an inverse agonist, to allosteric angiogenic receptors in cocultures of human endothelial cells is reported.

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