Bloom helicase mediates formation of large single–stranded DNA loops during DNA end processing

Chaoyou Xue; Sameer J. Salunkhe; Nozomi Tomimatsu; Ajinkya S. Kawale; Youngho Kwon; Sandeep Burma; Patrick Sung; Eric C. Greene

doi:10.1038/s41467-022-29937-7

Nature Communications (Apr 2022)

Bloom helicase mediates formation of large single–stranded DNA loops during DNA end processing

Chaoyou Xue,
Sameer J. Salunkhe,
Nozomi Tomimatsu,
Ajinkya S. Kawale,
Youngho Kwon,
Sandeep Burma,
Patrick Sung,
Eric C. Greene

Affiliations

Chaoyou Xue: Department of Biochemistry and Molecular Biophysics, Columbia University
Sameer J. Salunkhe: Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio
Nozomi Tomimatsu: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
Ajinkya S. Kawale: Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio
Youngho Kwon: Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio
Sandeep Burma: Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio
Patrick Sung: Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio
Eric C. Greene: Department of Biochemistry and Molecular Biophysics, Columbia University

DOI: https://doi.org/10.1038/s41467-022-29937-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Bloom syndrome is a genetic disorder associated with increased cancer risk and is caused by mutations in Bloom helicase. This study investigates the mechanisms used by BLM helicase as initiates the repair of broken chromosomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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