Nature Communications (Jun 2019)
Fcmr regulates mononuclear phagocyte control of anti-tumor immunity
- Shawn P. Kubli,
- Larsen Vornholz,
- Gordon Duncan,
- Wenjing Zhou,
- Parameswaran Ramachandran,
- Jerome Fortin,
- Maureen Cox,
- SeongJun Han,
- Robert Nechanitzky,
- Duygu Nechanitzky,
- Bryan E. Snow,
- Lisa Jones,
- Wanda Y. Li,
- Jillian Haight,
- Andrew Wakeham,
- Mark R. Bray,
- Tak W. Mak
Affiliations
- Shawn P. Kubli
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Larsen Vornholz
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Gordon Duncan
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Wenjing Zhou
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Parameswaran Ramachandran
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Jerome Fortin
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Maureen Cox
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- SeongJun Han
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Robert Nechanitzky
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Duygu Nechanitzky
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Bryan E. Snow
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Lisa Jones
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Wanda Y. Li
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Jillian Haight
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Andrew Wakeham
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Mark R. Bray
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- Tak W. Mak
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre
- DOI
- https://doi.org/10.1038/s41467-019-10619-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Myeloid cells modulate the immune response within the tumour microenvironment, but the underlying mechanisms remain largely unknown. Here, the authors show that Fcmr – the putative receptor for soluble IgM – is a potent negative regulator of anti-tumour immunity.
