Interdyscyplinary management of verrucous carcinoma in renal transplant recipient on long term immunosuppression. Clinical report.

Abstract

Background: The high risk of human papillomavirus (HPV) related anogenital lesions that lead to cancer in immunosuppressed renal transplant recipients (RTRs) has been previously reported [1,2]. One of them, Verrucous carcinoma, is un uncommon low–grade squamous cell carcinoma (SCC) affecting skin and mucosa, often associated with chronic immunosuppression in patients after organ transplantation. RTRs are at overall increased risk of developing skin cancers, predominantly the non-melanoma subtypes, including malignances observed in recipients after preempive kidney transplantation (PKT) [3,4,5]. The introduction of primary prevention, continuous monitoring in patients with known high-risk HPV, necessity of early diagnosis and treatment, prevention of malignancies in transplant recipients and long-term managing maintaining adequate immunosuppressive therapy, are necessary [6,7].

Keywords

• Squamous Cell Carcinoma
• Renal Transplant Recipients
• Immunotherapy
• Human Papillomavirus