Frontiers in Neuroinformatics (Dec 2018)
An Automated Pipeline for the Analysis of PET Data on the Cortical Surface
- Arnaud Marcoux,
- Arnaud Marcoux,
- Arnaud Marcoux,
- Arnaud Marcoux,
- Arnaud Marcoux,
- Ninon Burgos,
- Ninon Burgos,
- Ninon Burgos,
- Ninon Burgos,
- Ninon Burgos,
- Anne Bertrand,
- Anne Bertrand,
- Anne Bertrand,
- Anne Bertrand,
- Anne Bertrand,
- Anne Bertrand,
- Marc Teichmann,
- Marc Teichmann,
- Marc Teichmann,
- Marc Teichmann,
- Marc Teichmann,
- Alexandre Routier,
- Alexandre Routier,
- Alexandre Routier,
- Alexandre Routier,
- Alexandre Routier,
- Junhao Wen,
- Junhao Wen,
- Junhao Wen,
- Junhao Wen,
- Junhao Wen,
- Jorge Samper-González,
- Jorge Samper-González,
- Jorge Samper-González,
- Jorge Samper-González,
- Jorge Samper-González,
- Simona Bottani,
- Simona Bottani,
- Simona Bottani,
- Simona Bottani,
- Simona Bottani,
- Stanley Durrleman,
- Stanley Durrleman,
- Stanley Durrleman,
- Stanley Durrleman,
- Stanley Durrleman,
- Marie-Odile Habert,
- Marie-Odile Habert,
- Marie-Odile Habert,
- Olivier Colliot,
- Olivier Colliot,
- Olivier Colliot,
- Olivier Colliot,
- Olivier Colliot,
- Olivier Colliot,
- for the Alzheimer's Disease Neuroimaging Initiative
Affiliations
- Arnaud Marcoux
- Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
- Arnaud Marcoux
- Inserm, U 1127, Paris, France
- Arnaud Marcoux
- CNRS, UMR 7225, Paris, France
- Arnaud Marcoux
- Sorbonne Université, Paris, France
- Arnaud Marcoux
- Inria, Aramis Project-Team, Paris, France
- Ninon Burgos
- Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
- Ninon Burgos
- Inserm, U 1127, Paris, France
- Ninon Burgos
- CNRS, UMR 7225, Paris, France
- Ninon Burgos
- Sorbonne Université, Paris, France
- Ninon Burgos
- Inria, Aramis Project-Team, Paris, France
- Anne Bertrand
- Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
- Anne Bertrand
- Inserm, U 1127, Paris, France
- Anne Bertrand
- CNRS, UMR 7225, Paris, France
- Anne Bertrand
- Sorbonne Université, Paris, France
- Anne Bertrand
- Inria, Aramis Project-Team, Paris, France
- Anne Bertrand
- AP-HP, Departments of Neuroradiology and Neurology, Pitié-Salpétriére Hospital, Paris, France
- Marc Teichmann
- Inserm, U 1127, Paris, France
- Marc Teichmann
- CNRS, UMR 7225, Paris, France
- Marc Teichmann
- Sorbonne Université, Paris, France
- Marc Teichmann
- Institut du Cerveau et de la Moelle épinière, ICM, FrontLab, Paris, France
- Marc Teichmann
- Department of Neurology, National Reference Center for “PPA and rare dementias”, Institute for Memory and Alzheimer's Disease, Pitié Salpêtrière Hospital, AP-HP, Paris, France
- Alexandre Routier
- Inserm, U 1127, Paris, France
- Alexandre Routier
- CNRS, UMR 7225, Paris, France
- Alexandre Routier
- Sorbonne Université, Paris, France
- Alexandre Routier
- Inria, Aramis Project-Team, Paris, France
- Alexandre Routier
- Institut du Cerveau et de la Moelle épinière, ICM, FrontLab, Paris, France
- Junhao Wen
- Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
- Junhao Wen
- Inserm, U 1127, Paris, France
- Junhao Wen
- CNRS, UMR 7225, Paris, France
- Junhao Wen
- Sorbonne Université, Paris, France
- Junhao Wen
- Inria, Aramis Project-Team, Paris, France
- Jorge Samper-González
- Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
- Jorge Samper-González
- Inserm, U 1127, Paris, France
- Jorge Samper-González
- CNRS, UMR 7225, Paris, France
- Jorge Samper-González
- Sorbonne Université, Paris, France
- Jorge Samper-González
- Inria, Aramis Project-Team, Paris, France
- Simona Bottani
- Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
- Simona Bottani
- Inserm, U 1127, Paris, France
- Simona Bottani
- CNRS, UMR 7225, Paris, France
- Simona Bottani
- Sorbonne Université, Paris, France
- Simona Bottani
- Inria, Aramis Project-Team, Paris, France
- Stanley Durrleman
- Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
- Stanley Durrleman
- Inserm, U 1127, Paris, France
- Stanley Durrleman
- CNRS, UMR 7225, Paris, France
- Stanley Durrleman
- Sorbonne Université, Paris, France
- Stanley Durrleman
- Inria, Aramis Project-Team, Paris, France
- Marie-Odile Habert
- AP-HP, Hôpital Pitié-Salpêtrière, Department of Nuclear Medicine, Paris, France
- Marie-Odile Habert
- 0Laboratoire d'Imagerie Biomédicale, Sorbonne Universités, UPMC Univ Paris 06, Inserm U 1146, CNRS UMR 7371, Paris, France
- Marie-Odile Habert
- 1Centre Acquisition et Traitement des Images, Paris, France
- Olivier Colliot
- Institut du Cerveau et de la Moelle épinière, ICM, Paris, France
- Olivier Colliot
- Inserm, U 1127, Paris, France
- Olivier Colliot
- CNRS, UMR 7225, Paris, France
- Olivier Colliot
- Sorbonne Université, Paris, France
- Olivier Colliot
- Inria, Aramis Project-Team, Paris, France
- Olivier Colliot
- AP-HP, Departments of Neuroradiology and Neurology, Pitié-Salpétriére Hospital, Paris, France
- for the Alzheimer's Disease Neuroimaging Initiative
- DOI
- https://doi.org/10.3389/fninf.2018.00094
- Journal volume & issue
-
Vol. 12
Abstract
We present a fully automatic pipeline for the analysis of PET data on the cortical surface. Our pipeline combines tools from FreeSurfer and PETPVC, and consists of (i) co-registration of PET and T1-w MRI (T1) images, (ii) intensity normalization, (iii) partial volume correction, (iv) robust projection of the PET signal onto the subject's cortical surface, (v) spatial normalization to a template, and (vi) atlas statistics. We evaluated the performance of the proposed workflow by performing group comparisons and showed that the approach was able to identify the areas of hypometabolism characteristic of different dementia syndromes: Alzheimer's disease (AD) and both the semantic and logopenic variants of primary progressive aphasia. We also showed that these results were comparable to those obtained with a standard volume-based approach. We then performed individual classifications and showed that vertices can be used as features to differentiate cognitively normal and AD subjects. This pipeline is integrated into Clinica, an open-source software platform for neuroscience studies available at www.clinica.run.
Keywords