PERSONALIZED APPROACH TO TREATMENT OF CHRONIC INFLAMMATORY DISEASES OF THE UPPER GASTROINTESTINAL TRACT IN CHILDREN WITH CYP2C19 POLYMORPHISM ACCOUNT

Abstract

Purpose: the personification approach to the choice of antisecretory drugs in chronic gastroduodenitis, gastroesophagealreflux disease in children.Materials and methods: The study involved 70 children (12-14 years) with chronic inflammatory diseases of the upper digestive tract (WOCAT) (gastroesophageal reflux disease (GERD) in conjunction with chronic gastroduodenitis (CGD)). All children performed esophagogastroduodenoscopy (machine Olympus) with biopsy mucosa (CO) of the distal esophagus, gastric antrum, duodenum and molecular genetic research aimed at identifying gene polymorphism CYP2C19 * 2.Results: 50.2% of children surveyed were identified, rapid metabolizers (RM), while 28.4% of intermediate metabolizers (PM) of proton pump inhibitors (PPIs), while slow metabolizers (SM) IPP in 21.4% of cases .Conclusion: the continuing high activity of gastritis after standard therapy in children with RM/ PM IPP suggests the need for a personalized approach to the choice of antisecretory therapy based on gene polymorphism CYP2C19*2.Personalized approach to treatment of chronicinflammatory diseases of the upper gastrointestinaltract in children with CYP2C19 polymorphismaccount

Keywords

• cyp2c19
• chronic gastroduodenitis
• proton pump inhibitors