RMD Open (Apr 2024)
Use of risk chart algorithms for the identification of psoriatic arthritis patients at high risk for cardiovascular disease: findings derived from the project CARMA cohort after a 7.5-year follow-up period
- ,
- Jesús Tornero,
- Alba Erra,
- Santos Castañeda,
- Carolina Pérez-García,
- Raimon Sanmartí,
- Sara Marsal,
- Ingrid Moller,
- Esperanza Naredo,
- Miguel A González-Gay,
- Celia Erausquin,
- Ivan Castellví,
- Javier Llorca,
- Alejandro Muñoz,
- María Galindo,
- Enrique Raya,
- Lydia Abasolo,
- Gema Bonilla,
- Alfonso Corrales,
- Inmaculada Ureña,
- Carlos Rodríguez-Lozano,
- Carlos González-Juanatey,
- Cristina Fernandez Carballido,
- Francisco J López-Longo,
- Miguel Ángel González-Gay,
- Eduardo Collantes,
- José A Miranda-Filloy,
- Sagrario Bustabad,
- Indalecio Monteagudo,
- Jose A Piqueras,
- Tatiana Cobo,
- Joan Maymó,
- Carmen Barbadillo,
- Soledad Ojeda,
- Jaime Calvo Alen,
- Antonio Fernandez Nebro,
- Isabel Rodríguez,
- Pilar Font,
- Martina Steiner,
- Eugenio Chamizo Carmona,
- Beatriz González Álvarez,
- Santiago Munoz,
- Joan M Nolla,
- Fernando Sánchez-Alonso,
- Julio Sanchez,
- Raul Menor Almagro,
- Ana Pérez Gómez,
- Monica Ibañez,
- Elena Heras-Recuero,
- Trinidad Pérez Sandoval,
- Miren Uriarte-Ecenarro,
- Angela Pecondón,
- Hye Sang Park,
- Jessica Polo y La Borda,
- Zulema Plaza,
- Carmen García Gómez,
- Ivan Ferraz-Amaro,
- Jesús Tomás Sanchez-Costa,
- Olga Carmen Sánchez-González,
- Ana Isabel Turrión-Nieves,
- Ana Perez-Alcalá,
- José L FernándezSueiro,
- José A Pinto-Tasende,
- Eugenia Gonzálezde Rábago,
- María J González-Fernández,
- Ramón Huguet Codina,
- Beatriz Yoldi,
- Mercedes Ramentol,
- Gabriela Ávila,
- Cayetano Alegre,
- Fernando Gamero,
- José García Torón,
- María P Moreno-Gil,
- Antonio Juan-Mas,
- Pilar Espiño,
- Inmaculada Ros,
- Horacio Berman,
- Oscar Fontseré Patón,
- Benjamín Fernández Gutiérrez,
- José M Pina-Salvador,
- María D Fábregas,
- Montserrat Romera,
- Jesús A García-Vadillo,
- Rosario García de Vicuña,
- María A Belmonte,
- María V Irigoyen,
- Olga Martínez González,
- Rebeca Belmonte Gómez,
- Pastora Granados Bautista,
- Azucena Hernández Sanz,
- José Santos Rey,
- Carmen O Sánchez-González,
- Javier Bachiller,
- Antonio Zea,
- Francisco J Manero,
- Chesús Beltrán Audera,
- Marta Medrano,
- Jesús Babío Herráez,
- Javier del Pino,
- Ruth López González,
- María Enriqueta Peiró,
- José M Senabre,
- José C Rosas,
- Isabel Rotés,
- Estefanía Moreno,
- Javier Calvo,
- Amalia Rueda,
- Pilar Morales,
- Ana Nieto,
- Ana Ruibal Escribano,
- Carmen García Gómez,
- Sergio Ros Expósito,
- Ginés Sánchez Nievas,
- Enrique Júdez Navarro,
- Manuela Sianes Fernández,
- Silvia Martínez Pardo,
- Manel Pujol,
- Alberto Cantabrana,
- Esmeralda Delgado,
- Sergio Rodríguez Montero,
- Javier Rivera Redondo,
- Teresa González Hernández,
- Francisco J González-Polo,
- José M Moreno,
- Emilio Giner Serret,
- Laura Cebrián Méndez,
- María Teresa Navío,
- Teresa Pedraz Penalva,
- Encarnación Pagán,
- Pablo Mesadel Castillo,
- Ana Cruz,
- Ana Turrión,
- Desireé Ruíz,
- Antonio López Meseguer,
- Manuel J Moreno,
- Luis F Linares,
- Mercedes Morcillo,
- María L González-Gómez,
- José M Aramburu,
- Natalia A Rivera,
- Olaia Fernández Berrizbeitia,
- Manel Riera,
- Yolanda María León,
- Miriam Amirall,
- Jordi Fiter,
- Julia Fernández Melón,
- Luis Espadaler,
- Joaquín Belzunegui,
- Inmaculada Bañegil,
- César Díaz,
- Ramón Valls,
- María Bonet,
- Eva Revuelta Evrard,
- Javier R Godo,
- José A González-Fernández
Affiliations
- Jesús Tornero
- H Guadalajara, Guadalajara, Spain
- Alba Erra
- Vall Hebron H, Barcelona, Spain
- Santos Castañeda
- Reference hospitals, Rheumatology and Dermatology, Spain
- Carolina Pérez-García
- HOSPITAL DEL MAR, RHEUMATOLOGY, BARCELONA, Spain
- Raimon Sanmartí
- H Clinic, Barcelona, Spain
- Sara Marsal
- Vall Hebron H, Barcelona, Spain
- Ingrid Moller
- 5Institut Poal de Reumatologia, Barcelona, Spain
- Esperanza Naredo
- 4Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
- Miguel A González-Gay
- Marqués de Valdecilla University Hospital, Santander, Spain
- Celia Erausquin
- Ivan Castellví
- 2Hospital de la Santa Creu Y Sant Pau, Barcelona, Spain
- Javier Llorca
- 11Dept. of Epidemiology and Computational Biology, School of Medicine, Univ. of Cantabria, and CIBERESP, IDIVAL, Santander, Spain
- Alejandro Muñoz
- Hospital Universitario Virgen del Rocío, Rheumatology, Sevilla, Spain
- María Galindo
- Enrique Raya
- 18Hospital San Cecilio, Granada, Spain
- Lydia Abasolo
- Insituto de Investigacion Sanitaria San Carlos, Madrid, Spain
- Gema Bonilla
- Alfonso Corrales
- Hospital de Investigacion Sanitaria Valdecilla, Santander, Spain
- Inmaculada Ureña
- UCG of Rheumatology at the Hospital Regional Universitario de Málaga (HRUM). Institute for Biomedical Research in Malaga (IBIMA). Malaga University1, Malaga, Spain
- Carlos Rodríguez-Lozano
- Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain
- Carlos González-Juanatey
- 14 Cardiology, Hospital Universitario Lucus Augusti, Lugo, Spain
- Cristina Fernandez Carballido
- Francisco J López-Longo
- 9H.G.U. Gregorio Marañón, Madrid, Spain
- Miguel Ángel González-Gay
- 3 Rheumatology, ISS Fundacion Jimenez Diaz, Madrid, Spain
- Eduardo Collantes
- José A Miranda-Filloy
- Sagrario Bustabad
- Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
- Indalecio Monteagudo
- 3H.G.U. Gregorio Marañón, Madrid, Spain
- Jose A Piqueras
- Tatiana Cobo
- Joan Maymó
- Carmen Barbadillo
- Hospital Puerta de Hierro-Majadahonda, Majadahonda, Spain
- Soledad Ojeda
- Reference hospitals, Rheumatology and Dermatology, Spain
- Jaime Calvo Alen
- Antonio Fernandez Nebro
- 4UGC Reumatología, Instituto de Investigación Biomédica (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain
- Isabel Rodríguez
- Pilar Font
- Martina Steiner
- 3Hospital Universitario Infanta Sofia, Madrid, Spain
- Eugenio Chamizo Carmona
- Beatriz González Álvarez
- Santiago Munoz
- Joan M Nolla
- Fernando Sánchez-Alonso
- Spanish Society of Rheumatology (SER), Madrid, Spain
- Julio Sanchez
- H. 12 de Octubre, Madrid, Spain
- Raul Menor Almagro
- 10Hospital de Jerez, Jerez de la Frontera, Spain
- Ana Pérez Gómez
- Hospital Universitario Príncipe de Asturias, Madrid, Spain
- Monica Ibañez
- Elena Heras-Recuero
- 3 Rheumatology, ISS Fundacion Jimenez Diaz, Madrid, Spain
- Trinidad Pérez Sandoval
- 21H. León, León, Spain
- Miren Uriarte-Ecenarro
- Angela Pecondón
- Hye Sang Park
- Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
- Jessica Polo y La Borda
- 1 Rheumatology, Hospital Universitario Rey Juan Carlos, Madrid, Spain
- Zulema Plaza
- 5 Research Unit, Spanish Society of Rheumatology, Madrid, Spain
- Carmen García Gómez
- 6 Rheumatology, Consorci Sanitari de Terrassa, Barcelona, Spain
- Ivan Ferraz-Amaro
- Hospital Universitario de Canarias, Rheumatology, San Cristobal de la Laguna, Spain
- Jesús Tomás Sanchez-Costa
- 9 Rheumatology, Research Unit, Spanish Society of Rheumatology, Madrid, Spain
- Olga Carmen Sánchez-González
- 10 Rheumatology, Hospital Universitario del Sureste, Madrid, Spain
- Ana Isabel Turrión-Nieves
- 11 Rheumatology Department, Hospital Complejo Asistencial Universitario de Salamanca, Salamanca, Spain
- Ana Perez-Alcalá
- 12 Rheumatology, Hospital Universitario Príncipe Asturias, Alcalá de Henares, Madrid, Spain
- José L FernándezSueiro
- José A Pinto-Tasende
- Eugenia Gonzálezde Rábago
- María J González-Fernández
- Ramón Huguet Codina
- Beatriz Yoldi
- Mercedes Ramentol
- Gabriela Ávila
- Cayetano Alegre
- Fernando Gamero
- Reference hospitals, Rheumatology, Ophthalmology and Internal Medicine Units, Spain
- José García Torón
- María P Moreno-Gil
- Antonio Juan-Mas
- Pilar Espiño
- Inmaculada Ros
- 6H Son Llàtzer, Palma de Mallorca, Spain
- Horacio Berman
- Oscar Fontseré Patón
- Benjamín Fernández Gutiérrez
- José M Pina-Salvador
- María D Fábregas
- Montserrat Romera
- 6Hospital de Bellvitge, L’Hospitalet de Llobregat, Spain
- Jesús A García-Vadillo
- Rosario García de Vicuña
- 4Hospital Universitario La Princesa, IIS-IP, Rheumathology, Madrid, Spain
- María A Belmonte
- María V Irigoyen
- Olga Martínez González
- H. Salamanca, Salamanca, Spain
- Rebeca Belmonte Gómez
- Pastora Granados Bautista
- Azucena Hernández Sanz
- José Santos Rey
- Carmen O Sánchez-González
- Javier Bachiller
- Antonio Zea
- HU Ramón y Cajal, Madrid, Spain
- Francisco J Manero
- Chesús Beltrán Audera
- Marta Medrano
- Jesús Babío Herráez
- Javier del Pino
- Hospital Universitario de Salamanca, Salamanca, Spain
- Ruth López González
- 13H.U. Virgen de la Concha, Zamora, Spain
- María Enriqueta Peiró
- José M Senabre
- José C Rosas
- Isabel Rotés
- Estefanía Moreno
- Javier Calvo
- 10Hospital General Universitario de Valencia, Valencia, Spain
- Amalia Rueda
- Pilar Morales
- Ana Nieto
- Ana Ruibal Escribano
- Carmen García Gómez
- Sergio Ros Expósito
- Ginés Sánchez Nievas
- 1Complejo Hospitalario Universitario de Albacete, Rheumatology, Albacete, Spain
- Enrique Júdez Navarro
- 1Complejo Hospitalario Universitario de Albacete, Rheumatology, Albacete, Spain
- Manuela Sianes Fernández
- Silvia Martínez Pardo
- HU Mutua Terrrassa, Terrassa, Barcelona, Spain
- Manel Pujol
- 1Hospital Universitari Mutua de Terrassa, Rheumatology, Terrassa, Spain
- Alberto Cantabrana
- Esmeralda Delgado
- Sergio Rodríguez Montero
- Valme Hospital, Rheumatology, Seville, Spain
- Javier Rivera Redondo
- Teresa González Hernández
- Francisco J González-Polo
- José M Moreno
- Emilio Giner Serret
- Laura Cebrián Méndez
- María Teresa Navío
- Teresa Pedraz Penalva
- Encarnación Pagán
- Pablo Mesadel Castillo
- Ana Cruz
- Ana Turrión
- Desireé Ruíz
- Reina Sofia University Hospital, Rheumatology, Crdoba, Spain
- Antonio López Meseguer
- Manuel J Moreno
- Luis F Linares
- Mercedes Morcillo
- María L González-Gómez
- José M Aramburu
- Natalia A Rivera
- Olaia Fernández Berrizbeitia
- Manel Riera
- 2HOSPITAL DOS DE MAIG, BARCELONA, Spain
- Yolanda María León
- Miriam Amirall
- Jordi Fiter
- Julia Fernández Melón
- Luis Espadaler
- Joaquín Belzunegui
- 35H.U. Donostia, San Sebastián, Spain
- Inmaculada Bañegil
- César Díaz
- Ramón Valls
- María Bonet
- Eva Revuelta Evrard
- Javier R Godo
- José A González-Fernández
- DOI
- https://doi.org/10.1136/rmdopen-2024-004207
- Journal volume & issue
-
Vol. 10,
no. 2
Abstract
Objective To assess the predictive value of four cardiovascular (CV) risk algorithms for identifying high-risk psoriatic arthritis (PsA) patients.Methods Evaluation of patients with PsA enrolled in the Spanish prospective project CARdiovascular in RheuMAtology. Baseline data of 669 PsA patients with no history of CV events at the baseline visit, who were followed in rheumatology outpatient clinics at tertiary centres for 7.5 years, were retrospectively analysed to test the performance of the Systematic Coronary Risk Assessment (SCORE), the modified version (mSCORE) European Alliance of Rheumatology Associations (EULAR) 2015/2016, the SCORE2 algorithm (the updated and improved version of SCORE) and the QRESEARCH risk estimator version 3 (QRISK3).Results Over 4790 years of follow-up, there were 34 CV events, resulting in a linearised rate of 7.10 per 1000 person-years (95% CI 4.92 to 9.92). The four CV risk scales showed strong correlations and all showed significant associations with CV events (p<0.001). SCORE, mSCORE EULAR 2015/2016 and QRISK3 effectively differentiated between low and high CV risk patients, although the cumulative rate of CV events observed over 7.5 years was lower than expected based on the frequency predicted by these risk scales. Additionally, model improvement was observed when combining QRISK3 with any other scale, particularly the combination of QRISK3 and SCORE2, which yielded the lowest Akaike information criterion (411.15) and Bayesian information criterion (420.10), making it the best predictive model.Conclusions Risk chart algorithms are very useful for discriminating PsA at low and high CV risk. An integrated model featuring QRISK3 and SCORE2 yielded the optimal synergy of QRISK3’s discrimination ability and SCORE2’s calibration accuracy.