Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application

• Dan Li,
• Zhou Fang,
• Qiang Shi,
• Nicholas Zhang,
• Binsheng Gong,
• Weida Tong,
• Ahmet F. Coskun,
• Joshua Xu

Affiliations

Dan Li

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA

Zhou Fang

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA; Machine Learning Graduate Program, Georgia Institute of Technology, Atlanta, GA, 30332, USA

Qiang Shi

Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA

Nicholas Zhang

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA; Interdisciplinary Bioengineering Graduate Program, Georgia Institute of Technology, Atlanta, GA, 30332, USA

Binsheng Gong

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA

Weida Tong

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA

Ahmet F. Coskun

Corresponding author. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA; Interdisciplinary Bioengineering Graduate Program, Georgia Institute of Technology, Atlanta, GA, 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA

Joshua Xu

Corresponding author.; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA