Clinical symptoms in IgA deficiency

Abstract

Background: IgA deficiency is the most common primary immunodeficiency. Early diagnosis and clinical follow-up may improve the quality of life of patients with IgA deficiency. To this end, IgA deficiency should be further studied and better understood on its clinical manifestations. Objective: To determine IgA deficiency clinical manifestations. Methods: Cross-sectional, retrospective, exploratory study, where the medical records of 39 patients with IgA deficiency were analyzed. Results: Among the analyzed cases, 10 patients were diagnosed with total IgA deficiency and 29 patients with partial IgA deficiency. Partial and total IgA deficiency main clinical manifestations were allergic rhinoconjunctivitis and allergic asthma. In total IgA deficiency, in addition to allergic diseases, a statistically significant number (P < 0.05) of cases of infection-related rhinosinusitis, tonsillitis and conjunctivitis were also observed. Conclusion: This study showed that the main clinical manifestations in IgA deficiency were allergic rhinoconjunctivitis and allergic asthma. In addition, patients with total IgA deficiency showed a significant increase in infection-related rhinosinusitis, tonsillitis and conjunctivitis, when compared with patients with partial IgA deficiency.

Keywords

• Inmunodeficiencias primarias
• Deficiencia de inmunoglobulina A
• Deficiencia de anticuerpos