Green synthesis of 2-aryl-4-phenyl-quınazolıne derıvatives promoted by lactıc acıd

Abstract

An environmentally benign three-component synthetic method is described for the construction of 2-aryl-4-phenylquinazoline derivatives from the reaction between aldehydes, ammonium acetate, and 2-aminobenzophenone in the presence of lactic acid in a solvent-less media. The benefits of the reaction were good yields, a simple procedure, simple starting materials short reaction time, easy work-up, and cleaner reaction profiles.

Keywords

• green protocol
• quinazoline derivatives
• multi-component reaction
• lactic acid
• solvent-free conditions