Атеросклероз (Dec 2015)
Interrelation of leptin levels in blood and the main components of metabolic syndrome among oilmen working in the oil industry in Western Siberia
Abstract
The purpose of this research is to examine leptin levels in blood serum and frequency of the main components of metabolic syndrome among oilmen working in shifts in Western Siberia. Materials and methods: The research design is solid and cross-sectional. The research object is 125 men working in the oil industry in Western Siberia at the age of 30.2–45.7 (mean age is 35.3±3.5). Examination methods are anthropometry, measurement of blood pressure, electrocardiogram and determination of total cholesterol, glucose, leptin and C-peptid in blood plasma. Statistical data processing was performed using the Statistica 8.0 software package. Results: 73.60 % of the examined had certain components of metabolic syndrome: abdominal obesity (32.8 %), hypertension (23.2 %), hypercholesterolemia (59.2 %). The combination of these features was observed in 52.17 % of cases. 43.2 % of oilmen had overweight, 36.0 % – high normal blood pressure. Leptin concentrations in plasma fluctuated within 0.22–140.06 ng/ml (mean value is 16.93±21.19 ng/ml). C-peptid concentrations in plasma fluctuated within 0.01–6.19 mmol/l (mean value is 0.46±0.71 mmol/l). Conclusion: There were revealed essential differences between the leptin levels in the oilmen groups working in shifts with a normal BMI and obesity; with hypercholesterolemia and total cholesterol level below 5.1 mmol/L; with hyper-C-peptidemia and normal basal concentration of C-peptide (p ≤ 0.01). While estimating the binding force according to the scale Cheddoka, there was established a statistically significant p < 0.05 dependence between the concentration of leptin and C-peptide in plasma: it is reverse and noticeable.
