Urinary exosomes: Potential diagnostic markers and application in bladder cancer

Ji Liu; Zhang Zhijin; Wentao Zhang; Maskey Niraj; Fuhan Yang; Guo Changcheng; Liliang Shen; Tianyuan Xu; Shenghua Liu; Zhang Junfeng; Shiyu Mao; Wei Li; Xudong Yao

Heliyon (Jun 2024)

Urinary exosomes: Potential diagnostic markers and application in bladder cancer

Ji Liu,
Zhang Zhijin,
Wentao Zhang,
Maskey Niraj,
Fuhan Yang,
Guo Changcheng,
Liliang Shen,
Tianyuan Xu,
Shenghua Liu,
Zhang Junfeng,
Shiyu Mao,
Wei Li,
Xudong Yao

Affiliations

Ji Liu: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China
Zhang Zhijin: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China
Wentao Zhang: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China
Maskey Niraj: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China
Fuhan Yang: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China
Guo Changcheng: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China
Liliang Shen: Department of Urology, The Affiliated Yinzhou Renmin Hospital of Medical School of Ningbo University, Ningbo, 315040, China
Tianyuan Xu: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China
Shenghua Liu: Shanghai Huashan Hospital, Shanghai, 200433, China
Zhang Junfeng: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China
Shiyu Mao: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China; Corresponding author. Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Wei Li: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China; Corresponding author. Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
Xudong Yao: Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, 200331, China; Corresponding author. Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.

Journal volume & issue: Vol. 10, no. 12
p. e32621

Abstract

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Background: The exosome is a critical component of the intercellular communication., playing a vital role in regulating cell function. These small vesicles contain proteins, mRNAs, miRNAs, and lncRNAs, surrounded by lipid bilayer substances. Most cells in the human body can produce exosomes, released into various body fluids such as urine, blood, and cerebrospinal fluid. Bladder cancer is the most common tumor in the urinary system, with high recurrence and metastasis rates. Early diagnosis and treatment are crucial for improving patient outcomes. Methods: This study employed the PubMed search engine to retrieve publicly accessible data pertaining to urinary exosomes. Results: We summarize the origins and intricate biological characteristics of urinary exosomes, the introduction of research methodologies used in basic experiments to isolate and analyze these exosomes, the discussion of their applications and progress in the diagnosis and treatment of bladder cancer, and the exploration of the current limitations associated with using urinary exosomes as molecular biomarkers for diagnosing bladder cancer. Conclusion: Exosomes isolated from urine may be used as molecular biomarkers for early detection of bladder cancer.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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