ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II

Seina Ohe; Yuji Kubota; Kiyoshi Yamaguchi; Yusuke Takagi; Junichiro Nashimoto; Hiroko Kozuka-Hata; Masaaki Oyama; Yoichi Furukawa; Mutsuhiro Takekawa

doi:10.1038/s41467-022-35230-4

Nature Communications (Dec 2022)

ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II

Seina Ohe,
Yuji Kubota,
Kiyoshi Yamaguchi,
Yusuke Takagi,
Junichiro Nashimoto,
Hiroko Kozuka-Hata,
Masaaki Oyama,
Yoichi Furukawa,
Mutsuhiro Takekawa

Affiliations

Seina Ohe: Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo
Yuji Kubota: Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo
Kiyoshi Yamaguchi: Division of Clinical Genome Research, Institute of Medical Science, The University of Tokyo
Yusuke Takagi: Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo
Junichiro Nashimoto: Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo
Hiroko Kozuka-Hata: Medical Proteomics Laboratory, Institute of Medical Science, The University of Tokyo
Masaaki Oyama: Medical Proteomics Laboratory, Institute of Medical Science, The University of Tokyo
Yoichi Furukawa: Division of Clinical Genome Research, Institute of Medical Science, The University of Tokyo
Mutsuhiro Takekawa: Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-022-35230-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Growth factor-induced release of RNA Pol-II promoter-proximal pausing is vital for immediate-early gene expression, but its mechanism remains elusive. Here, the authors reveal roles of ERK and PP2A in this process and their dysregulation in cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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