A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

Thomas W Winkler; Felix Günther; Simon Höllerer; Martina Zimmermann; Ruth JF Loos; Zoltán Kutalik; Iris M Heid

doi:10.1038/s41467-018-04124-9

Nature Communications (May 2018)

A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

Thomas W Winkler,
Felix Günther,
Simon Höllerer,
Martina Zimmermann,
Ruth JF Loos,
Zoltán Kutalik,
Iris M Heid

Affiliations

Thomas W Winkler: Department of Genetic Epidemiology, University of Regensburg
Felix Günther: Department of Genetic Epidemiology, University of Regensburg
Simon Höllerer: Department of Genetic Epidemiology, University of Regensburg
Martina Zimmermann: Department of Genetic Epidemiology, University of Regensburg
Ruth JF Loos: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Zoltán Kutalik: Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV)
Iris M Heid: Department of Genetic Epidemiology, University of Regensburg

DOI: https://doi.org/10.1038/s41467-018-04124-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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In GWAS, waist-to-hip ratio (WHR) is often adjusted for body mass index (BMI) to account for their correlation (WHRadjBMI). Here, Winkler et al. classify 159 genetic variants for BMI, WHR, or WHRadjBMI based on their effect directions for BMI and WHR to differentiate subtypes of adiposity genetics.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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