Nature Communications (Apr 2022)

A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis

  • Lei Zhang,
  • James E. Kent,
  • Meredith Whitaker,
  • David C. Young,
  • Dominik Herrmann,
  • Alexander E. Aleshin,
  • Ying-Hui Ko,
  • Gino Cingolani,
  • Jamil S. Saad,
  • D. Branch Moody,
  • Francesca M. Marassi,
  • Sabine Ehrt,
  • Michael Niederweis

DOI
https://doi.org/10.1038/s41467-022-29873-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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The pathogen Mycobacterium tuberculosis uses the siderophores called mycobactins and carboxymycobactins to acquire iron from the host. Here, Zhang et al. identify a protein that is important for siderophore secretion and for the pathogen’s growth in low-iron medium.