Nature Communications (Oct 2021)
Effectiveness of ChAdOx1 vaccine in older adults during SARS-CoV-2 Gamma variant circulation in São Paulo
- Matt D. T. Hitchings,
- Otavio T. Ranzani,
- Murilo Dorion,
- Tatiana Lang D’Agostini,
- Regiane Cardoso de Paula,
- Olivia Ferreira Pereira de Paula,
- Edlaine Faria de Moura Villela,
- Mario Sergio Scaramuzzini Torres,
- Silvano Barbosa de Oliveira,
- Wade Schulz,
- Maria Almiron,
- Rodrigo Said,
- Roberto Dias de Oliveira,
- Patricia Vieira Silva,
- Wildo Navegantes de Araújo,
- Jean Carlo Gorinchteyn,
- Jason R. Andrews,
- Derek A. T. Cummings,
- Albert I. Ko,
- Julio Croda
Affiliations
- Matt D. T. Hitchings
- Department of Biostatistics, College of Public Health & Health Professions, University of Florida
- Otavio T. Ranzani
- Barcelona Institute for Global Health, ISGlobal
- Murilo Dorion
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Tatiana Lang D’Agostini
- Disease Control Coordination of the São Paulo State Department of Health
- Regiane Cardoso de Paula
- Disease Control Coordination of the São Paulo State Department of Health
- Olivia Ferreira Pereira de Paula
- Disease Control Coordination of the São Paulo State Department of Health
- Edlaine Faria de Moura Villela
- Disease Control Coordination of the São Paulo State Department of Health
- Mario Sergio Scaramuzzini Torres
- Municipal Health Secretary of Manaus
- Silvano Barbosa de Oliveira
- Pan American Health Organization
- Wade Schulz
- Department of Laboratory Medicine, Yale University School of Medicine
- Maria Almiron
- Pan American Health Organization
- Rodrigo Said
- Pan American Health Organization
- Roberto Dias de Oliveira
- State University of Mato Grosso do Sul - UEMS
- Patricia Vieira Silva
- Universidade Federal de Mato Grosso do Sul - UFMS
- Wildo Navegantes de Araújo
- Pan American Health Organization
- Jean Carlo Gorinchteyn
- Health Secretariat of the State of São Paulo
- Jason R. Andrews
- Division of Infectious Diseases and Geographic Medicine, Stanford University
- Derek A. T. Cummings
- Department of Biology, University of Florida
- Albert I. Ko
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Julio Croda
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- DOI
- https://doi.org/10.1038/s41467-021-26459-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
Here, the authors investigate the effectiveness of the Oxford-AstraZeneca (ChAdOx1) vaccine during extensive Gamma variant SARS-CoV-2 circulation in São Paulo state, Brazil, and find that a two-dose regime is more effective than one dose against mild to severe Covid-19 outcomes in older adults.
