Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

Yonatan R. Lewis-Israeli; Aaron H. Wasserman; Mitchell A. Gabalski; Brett D. Volmert; Yixuan Ming; Kristen A. Ball; Weiyang Yang; Jinyun Zou; Guangming Ni; Natalia Pajares; Xanthippi Chatzistavrou; Wen Li; Chao Zhou; Aitor Aguirre

doi:10.1038/s41467-021-25329-5

Nature Communications (Aug 2021)

Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

Yonatan R. Lewis-Israeli,
Aaron H. Wasserman,
Mitchell A. Gabalski,
Brett D. Volmert,
Yixuan Ming,
Kristen A. Ball,
Weiyang Yang,
Jinyun Zou,
Guangming Ni,
Natalia Pajares,
Xanthippi Chatzistavrou,
Wen Li,
Chao Zhou,
Aitor Aguirre

Affiliations

Yonatan R. Lewis-Israeli: Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University
Aaron H. Wasserman: Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University
Mitchell A. Gabalski: Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University
Brett D. Volmert: Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University
Yixuan Ming: Department of Biomedical Engineering, Washington University in Saint Louis
Kristen A. Ball: Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University
Weiyang Yang: Division of Biomedical Devices, Institute for Quantitative Health Science and Engineering, Michigan State University
Jinyun Zou: Department of Biomedical Engineering, Washington University in Saint Louis
Guangming Ni: Department of Biomedical Engineering, Washington University in Saint Louis
Natalia Pajares: Department of Chemical Engineering and Material Science, College of Engineering, Michigan State University
Xanthippi Chatzistavrou: Department of Chemical Engineering and Material Science, College of Engineering, Michigan State University
Wen Li: Division of Biomedical Devices, Institute for Quantitative Health Science and Engineering, Michigan State University
Chao Zhou: Department of Biomedical Engineering, Washington University in Saint Louis
Aitor Aguirre: Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University

DOI: https://doi.org/10.1038/s41467-021-25329-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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There is a pressing need to develop representative organ-like platforms recapitulating complex in vivo phenotypes to study human development and disease in vitro. Here the authors present a method to generate human heart organoids by self-assembly using pluripotent stem cells, compare these to age-matched fetal cardiac tissues and recreate a model of pregestational diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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